Solve your research thanks to microfluidics!

 

You don’t know what microfluidics can bring to your research? Let us help!

Microfluidics is the science of miniaturization that could bring a huge step forward to your research. Why miniaturize? Because it improves performances and opens up new possibilities. With the small size scales, scaling effects and handling with laminar flow only, you can improve, parallelize and integrate your research easily!

BlackHole Lab offers to carry a scientific and technical audit for your company by coming to your laboratory or company to see if some of your research and project can be done with microfluidics! 

  • The cost of your research will be significantly lower than with macro-scale device

  • Several functions can be integrated in your personalized device

  • Small volumes used in microfluidics lead to fast reactions

  • High surface-to-volume ratios enables to enhance sensitivity

Small size scales & Scalling effects

The micro scale induces unique chemical and physical features that occur in fluids, which allow to have several advantages over conventional “macro”-techniques (for example, surface tension, domination of fluidic resistance,… Micro and nano scales remain dominated by surface effects).

Typical sizes of microfluidics channels: width and height 10 – 100 µm, length 1mm – 1cm.
Typical volumes: 1µL for a microfluidic chip.

size-spectrum-of-particles-and-molecules

Microfluidics structures can be fabricated at roughly the same scale as analytes.

Laminar Flow

One of the property which is different from the macro scale is Reynolds number for example: with micro scale, it can become very low. It induces the possibility to have several fluids next to each other without any mixing as flow becomes laminar rather that turbulent.

laminar_versus_turbulent_flowTurbulent (left) vs. Laminar (right) flow

The laminar flow enables to have a slow mixing (in comparison with turbulent flow) by diffusion and to have better control on fluids than with turbulent flow.

Parallelization and Integration

integration_parallelizationThanks to the small size of microfluidic devices, it is possible to have a massive parallelization with several functions in only one chip which allows high-throughput analysis! For example, Lab-on-a-chip gather every functions needed for one application on only one chip! And this comes with a lot of advantages: safer platform for chemical or biological studies (as everything is inside the device without any additional handling), faster analysis and response times and thus better process control,…

Microfluidics is a field having a fast growth. Applications became more and more relevant in a lot of science fields, especially for life sciences (biomedical,…). You can find here some examples of applications of microfluidics.

 

Lung model (organ-on-a-chip)

lung-model_organ-on-a-chipAmong the parallelization possibilities of microfluidics, organ-on-a-chip is a promissing field. Lung on a chip is becoming a well known model and is based on the use of 2 layers of living tissues with 2 types of cells cultured on opposite sides of a stretchable (to mimic breathing) membrane. 
It can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing.

 

Drug delivery

drug-deliveryMicrofluidic systems have been increasingly used for fabrication of drug carriers and recent research activities have been used to study drug delivery (A. Khademhosseini et al.). Microfluidics can bring some transdermal microfluidic devices which could allow an easy and painless delivery of drugs to patient. This science mays enable the delivery of active molecules at cell, tissue and organ level.

 

Chemical microfluidics

  • Separation systems (Capillary Electrophoresis, Liquid and Gas chromatography,…)
  • Detectors (microelectrodes, Mass Spectrometry, photodiodes,…)
  • Droplet generators (Electrospray Ionization)
  • Ionization systems (Corona, UV,…)
  • Synthesis reactors
  • Gradient generators
  • Crystallization chips

dropletsExample of a part of a droplet chip.

gradient-generation_chip

Example of a gradient generation (PDMS chip).

Microfluidics for biology

  • Cell analysis (culture, separation or behavior)
  • Organ-on-a-chip
  • DNA sequencing
  • PCR amplification
  • Evolutionary biology
  • Biological assays

ELISA-test_microfluidics

Scheme of an ELISA test on 1 microfluidic chip.

Physical microfluidics

  • Cooling systems
  • Power-Microelectromechanical systems (Power-MEMS): combustion engines, fuel atomizers, fuel cells
  • Optofluidics (tunable mirolens arrays, optofluidic microscopes)
  • Fluid sensors (rate, viscosity, shear,…)

CUSTOM MADE SERVICES

We offer our expertise in microfluidics and microfabrication to advise you about the potnetial of microfluidics for your research. You can take the benefit of :

  • expertise and accompaniment
  • personalized services
  • responsiveness and care to details

Take the plunge !

Non contractual pictures – BlackHole Lab reserves the right to modify any item without prior notice

For general information

For further information, do not hesitate to contact our team of experts:

contact@blackholelab.com or phone: +33(0).782.831.207

Contact-Us-soft lithography PDMS chip Button